Protein Modification Reagents
Medchemexpress LLC Peg4-aminooxy-mmaf | 1415246-35-3 | 99.8% | 923.19 g/mol | C47H82N6O12 | 1 MG
PEG4-aminooxy-MMAF is a drug-linker conjugate used in the preparation of antibody-drug conjugates (ADCs). It pairs the antitubulin payload monomethyl auristatin F (MMAF) with a noncleavable PEG4 aminooxy linker to allow stable conjugation and targeted delivery of the cytotoxic agent for research applications.
- Stable noncleavable PEG4 aminooxy linker for antibody conjugation.
- Contains the antitubulin payload monomethyl auristatin F (MMAF).
- High purity as reported by supplier (99.83%).
- Available in small milligram quantities for research use.
- Intended for research use only; not validated for clinical use.
Medchemexpress LLC Fmoc-NH-PEG4-CH2COOH | 437655-95-3 | 99.1% | 473.52 | C25H31NO8 | 5 G
Fmoc-NH-PEG4-CH2COOH is an Fmoc-protected PEG4 linker bearing a terminal carboxylic acid. It is used as a cleavable ADC linker and as a PEG-based PROTAC linker for conjugation and linker synthesis. The compound has molecular formula C25H31NO8 and molecular weight 473.52 and is supplied at high purity for research use.
- Fmoc-protected amine compatible with solid-phase and solution-phase synthesis.
- Terminal carboxylic acid enables standard coupling reactions.
- Peg4 spacer increases solubility and provides linker flexibility.
- High purity suitable for research and conjugation chemistry.
- Available in multiple sizes, including a 5 g package.
Sigma Aldrich Fine Chemicals Biosciences DL-Dithiothreitol >=99.0% (RT) | 3483-12-3 | MFCD00004877 | 25G
DL-Dithiothreitol >=99.0% (RT) | Purity: >=99.0% (RT) | Mol Wt: 154.25 | 3483-12-3 | MFCD00004877 | 25G
Medchemexpress LLC HS-PEG-SH (MW 3400) | 97.0% | 50 MG
HS-PEG-SH (MW 3400) is a linear homobifunctional PEG cross-linker designed for various biochemical applications. It is utilized in drug delivery systems and for the preparation of PEG hydrogels, offering versatility for research purposes. This product has an average molecular weight of 3400 and a purity of 97.0%.
- Linear homobifunctional PEG
- Cross-linker for biochemical applications
- Utilized for drug delivery
- Suitable for preparing PEG hydrogels
- 97.0% purity
- Average molecular weight of 3400
- Appears as a solid
- Color ranges from white to light yellow
Medchemexpress LLC Propargyl-PEG4-CH2COOH | 1429934-37-1 | >97.0% | 290.31 | 25 MG
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It acts as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide-containing molecules. PROTACs, composed of two ligands linked together, target an E3 ubiquitin ligase and a specific protein, thereby utilizing the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Features Alkyne group for CuAAc
- Enables selective protein degradation via ubiquitin-proteasome system
Medchemexpress LLC endo-BCN-PEG2-alcohol | 1807501-85-4 | 98.0% | 325.40 | 25 MG
endo-BCN-PEG2-alcohol is a PEG-based PROTAC linker employed in the synthesis of PROTACs. This compound functions as a click chemistry reagent, featuring a BCN group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Functions as a click chemistry reagent.
- Contains a BCN group for strain-promoted alkyne-azide cycloaddition (SPAAC).
eMolecules Ald-Ph-PEG3-amine | 1404111-56-3 | MFCD28155203 | 500mg
Broadpharm | Ald-Ph-PEG3-amine | 500mg | 266683177 | BP-22387 | 95.000 | 1404111-56-3 | MFCD28155203 | 324.377 | C16H24N2O5
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eMolecules Mal-amido-PEG4-TFP ester | 1807540-84-6 | MFCD28505515 | 5g
Broadpharm | Mal-amido-PEG4-TFP ester | 5g | 550804212 | BP-22740 | 98.000 | 1807540-84-6 | MFCD28505515 | 564.487 | C24H28F4N2O9
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Medchemexpress LLC 3,6,9-trioxa-12-azaheptadecan-17-oic acid, 1-amino-16-[[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)m | 710323-40-3 | 99.7% | 615.64 | C27H37N9O8 | 5 MG
Folate-PEG3-amine is a cleavable three-unit polyethylene glycol (PEG) linker bearing a terminal primary amine and a folate-targeting moiety. It is designed for use as a spacer in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates, facilitating folate receptor-mediated targeting in research applications.
- Cleavable three-unit PEG spacer to separate payload and targeting ligand.
- Terminal primary amine for straightforward conjugation chemistries, such as NHS esters and activated carboxyls.
- High purity suitable for research (LCMS reported 99.69%).
- Water-soluble and compatible with common bioconjugation workflows.
- Supplied in small research quantities for experimental use.
Medchemexpress LLC 4,7,10,13-tetraoxa-16-azaheneicosanoic acid, 21-[(3as,4s,6ar)-hexahydro-2-oxo-1h-thieno[3,4 | 1334172-58-5 | 96.2% | 657.65 g/mol | C27H36F5N3O8S | 100 MG
Biotin-PEG4-PFP ester is a cleavable four-unit polyethylene glycol (PEG4) biotinylation reagent bearing a pentafluorophenyl (PFP) ester reactive group used for labeling and as an antibody-drug conjugate (ADC) linker. It is supplied for research use only.
- Cleavable PEG4 spacer increases hydrophilicity and reduces steric hindrance.
- PFP ester reactive group enables efficient conjugation to primary and secondary amines.
- High purity (96.18%) and available in multiple pack sizes, including 100 MG.
- Storage: powder at -20°C; in solvent stable at -80°C for 6 months or -20°C for 1 month.
- CAS number 1334172-58-5; molecular weight 657.65 g/mol; formula C27H36F5N3O8S.
Medchemexpress LLC H-151 alkyne (compound H-151-AL) | 2244892-03-1 | 95.1% | 275.30 g/mol | C17H13N3O | 10 MG
H-151 Alkyne is an alkyne-labeled derivative of H-151 that functions as a selective STING (Stimulator of Interferon Genes) inhibitor for research use. It is provided as a purified small molecule intended for biochemical and cell-based assays to probe STING-mediated signaling and related autoinflammatory or autoimmune disease mechanisms.
- Selective STING inhibition suitable for pathway studies.
- Alkyne handle enables click chemistry labeling and probe conjugation.
- Suitable for biochemical and cellular assays.
- High purity (95.1%) for reproducible results.
- Molecular weight 275.30 g/mol and formula C17H13N3O.
Medchemexpress LLC Methyltetrazine-PEG4-acid | 1802907-91-0 | 99.8% | C20H28N4O7 | 50 MG
Methyltetrazine-PEG4-acid is a PEG-based PROTAC linker designed for synthesizing PROTACs. It features methyltetrazine and carboxylic acid groups, enabling its use in copper-free click chemistry and reactions with primary amines.
- Suitable for copper-free click chemistry
- Reacts with primary amines
- PEG-based linker structure
- Utilized in PROTAC synthesis
- Stable under recommended storage conditions
- High purity (99.8%)
Broadpharm Fmoc-N-amido-PEG2-acid5g.Formula: C22H25NO6.CAS: 872679-70-4Purity: 98%
Fmoc-N-amido-PEG2-acid5g.Formula: C22H25NO6.CAS: 872679-70-4Purity: 98%